Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

作者：Espinoza Ingrid; Pochampally Radhika; Xing Fei; Watabe Kounosuke; Miele Lucio^*

来源：OncoTargets and Therapy, 2013, 6: 1249-1259.

DOI：10.2147/OTT.S36162

• Notch signaling
• EMT
• cancer stem cells
• mesenchymal stem cells
• metastases
• Notch inhibitors

Notch signaling is an evolutionarily conserved pathway involved in cell fate control during development, stem cell self-renewal, and postnatal tissue differentiation. Roles for Notch in carcinogenesis, the biology of cancer stem cells, tumor angiogenesis, and epithelial-to-mesenchymal transition (EMT) have been reported. This review describes the role of Notch in the %26quot;stemness%26quot; program in cancer cells and in metastases, together with a brief update on the Notch inhibitors currently under investigation in oncology. These agents may be useful in targeting cancer stem cells and to reverse the EMT process.

• 出版日期2013