Association of ABCB1 C3435T and C1236T gene polymorphisms with the susceptibility to acute myeloid leukemia in a Chinese population

作者：Li, Jingdong; Yang, Cui; Wang, Wanling; Han, Xiaolin; Sun, Ling^*

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(8): 8464-8470.

• ABCB1
• polymorphism
• acute myeloid leukemia
• Chinese population

We conducted a case-control study to investigate the role of ABCB1 C3435T (rs1045642) and C1236T (rs1128503) gene polymorphisms in the susceptibility to acute myeloid leukemia. The polymerase chain reaction (PCR) coupled with restriction fragment length polymorphism (RFLP) method was carried out to genotyping ABCB1 C3435T and C1236T gene polymorphism. Statistical analysis was conducted using the SPSS 17.0 package (SPSS Inc., Chicago, IL, USA). Using Chi-square test, a statistically significant difference was found between acute myeloid leukemia patients and control subjects with respect to ABCB1 C3435T (chi(2)=8.04, P=0.02). By unconditional logistic regression analysis, we found that the TT genotype of ABCB1 C3435T was associated with an increased risk of acute myeloid leukemia compared to the CC genotype (OR=2.24, 95% CI=1.22-4.12, P=0.01). In dominant model, the CT+TT genotype of ABCB1 C3435T was correlated with a higher risk of acute myeloid leukemia than the CC genotype (OR=1.68, 95% CI=1.07-2.65, P=0.02). In the recessive model, the TT genotype of ABCB1 C3435T contributed to the development of acute myeloid leukemia when compared to CC+CT genotype (OR=1.74, 95% CI=1.04-2.95). In our study, we suggested that the ABCB1 C3435T genetic polymorphism could influence the risk of developing adult acute myeloid leukemia in co-dominant, dominant and recessive models.

• 出版日期2016
• 单位新乡医学院; 郑州大学