Melatonin protects mast cells against cytotoxicity mediated by chemical stimuli PMACI: Possible clinical use

作者：Maldonado M D^*; Garcia Moreno H; Calvo J R

来源：Journal of Neuroimmunology, 2013, 262(1-2): 62-65.

DOI：10.1016/j.jneuroim.2013.06.013

• Melatonin
• RBL-2H3 mast cells
• Cytoprotection
• Immune system

Melatonin has documented cytoprotective effects on a wide variety of immune cells. The mechanism of action on mast cells (RBL-2H3) still remains in the dark. We found that melatonin significantly attenuated phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-induced cytotoxicity in a concentration and time-dependent manner. It appears that the effect of melatonin on mast cells is two-fold: dependent (MT1 and MT2) and independent membrane receptors. In conclusion, melatonin treatment reduced the cytotoxicity, mediated by PMACI, and could provide a useful therapeutic option in processes where an excessive activation of mast cells occurs.

• 出版日期2013-9-15