A highly efficient dual catalysis approach for C-glycosylation: addition of (o-azaaryl)carboxaldehyde to glycals

作者：Bai Yaguang; Leng Wei Lin; Li Yongxin; Liu Xue Wei^*

来源：Chemical communications, 2014, 50(87): 13391-13393.

DOI：10.1039/C4CC06111J

A novel and efficient dual catalysis approach by concurrent activation of glycals and (o-azaaryl)-carboxaldehydes using palladium and N-heterocyclic carbene has been developed. The two electrophiles could react after activation through formation of the Breslow intermediate and a pi-allyl Pd complex, widening the scope of reacting glycosylation partners and opening up possibilities for future glycosylation.

• 出版日期2014-11-11
• 单位南阳理工学院