Differential requirements for IL-4/STAT6 signalling in CD4 T-cell fate determination and Th2-immune effector responses

作者：Forbes Elizabeth; van Panhuys Nicholas; Min Booki; Le Gros Graham^*

来源：Immunology and Cell Biology, 2010, 88(3): 240-243.

DOI：10.1038/icb.2009.101

• Th2
• IL-4
• STAT6
• differentiation
• effector response

Improved analytical tools have revealed that the development and expression of a Th2 immune response can be broken down into distinct stages with respect to the cytokine microenvironment that is required. Although IL-4 and its STAT6-signalling pathway are critical for the expression of Th2 effector immune responses in peripheral tissues such as the skin, lung and gut, IL-4 and STAT6 signalling are not required for the initial generation of IL-4-producing Th2 cells in the lymph node. This finding reveals that we have yet to identify the key cytokine or microenvironment that stimulates the development of this most intriguing CD4( ) T-helper subset and emphasises the tissue specificity and timing of IL-4/STAT6-dependent Th2 effector responses. Immunology and Cell Biology (2010) 88, 240-243; doi: 10.1038/icb.2009.101; published online 15 December 2009

• 出版日期2010-4
• 单位河北医科大学