MRSA infections among patients in the emergency department: a European multicentre study

作者：Bouchiat C^*; Curtis S; Spiliopoulou I; Bes M; Cocuzza C; Codita I; Dupieux C; Giormezis N; Kearns A; Laurent F; Molinos S; Musumeci R; Prat C; Saadatian Elahi M; Tacconelli E; Tristan A; Schulte B; Vandenesch F

来源：Journal of Antimicrobial Chemotherapy, 2017, 72(2): 372-375.

DOI：10.1093/jac/dkw431

Background: MRSA is a therapeutic concern worldwide, and a major agent of community-acquired skin and soft tissue infections (CA-SSTIs). While the US epidemiology of MRSA in CA-SSTIs is well described and reports the high prevalence of the USA300 clone, data on the European situation are lacking.
Objectives: To determine the prevalence and clonal characteristics of MRSA in CA-SSTIs in seven European emergency departments.
Patients and methods: From April to June 2015, patients presenting to the tertiary hospital emergency department with a Staphylococcus aureus CA-SSTI were prospectively enrolled. S. aureus isolates were characterized by antimicrobial susceptibility testing, detection of Panton-Valentine leucocidin encoding genes and spa-typing, MLST and/or DNA microarray.
Results: Two-hundred and five cases of S. aureus-associated CA-SSTIs were included, comprising folliculitis, furuncles, abscesses, paronychia, impetigo, carbuncles and cellulitis. Of the 205 cases, we report an MRSA prevalence rate of 15.1%, with a north (0%) to south (29%) increasing gradient. Fifty-one isolates were Panton-Valentine leucocidin-positive (24.9%), whether MSSA or MRSA, with a heterogeneous distribution between countries. Clonal distribution of MSSA and MRSA showed high diversity, with no predominant circulating clone and no archetypical USA300 CA-MRSA clone.
Conclusions: This original prospective multicentre study highlights stark differences in European MRSA epidemiology compared with the USA, and that the USA300 CA-MRSA clone is not predominant among community-infected patients in Europe.

• 出版日期2017-2