A novel TRPC6-dependent mechanism of TGF-beta-induced migration and invasion of human hepatocellular carcinoma cells

作者：Tian, Yun; Zhu, Michael X.^*

来源：Science China Life Sciences, 2018, 61(9): 1120-1122.

DOI：10.1007/s11427-018-9365-7

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<正>Mechanisms on cancer cell migration and invasion have been major topics of cancer research and anti-cancer therapy development. Among the multiple cell signaling pathways involved in cell migration, those elicited by transforming growth factorβ(TGF-β) have attracted tremendous attention. The TGF-βpolypeptide cytokines include four isoforms:TGF-β1, TGF-β2, TGF-β3, and TGF-β4, which are secreted mainly from cells of white blood cell lineage, such as macrophages, T cells and platelets. However, TGF-βcan also be synthesized and released from fibroblasts and cancer

• 出版日期2018-9
• 单位湖南农业大学