The role of the cytokines in the pathogenesis of pseudoexfoliation syndrome

作者：Yildirim Zuhal^*; Yildirim Filiz; Ucgun Nil Irem; Sepici Dincel Aylin

来源：International Journal of Ophthalmology, 2013, 6(1): 50-53.

DOI：10.3980/j.issn.2222-3959.2013.01.10

• pseudoexfoliation syndrome
• inflammation
• vascular endothelial growth factor, interleukin-6
• interleukin-1 beta

AIM: To examine the mechanism of the development of pseudoexfoliation (PSX) syndrome via both cytokine formation and endothelial vasorelaxing and growth factors that will provide us new therapeutic insights for the treatment. %26lt;br%26gt;METHODS: This is a cross sectional study included two groups; Group 1: control patients with nuclear cataract(n=20, aged 51-80 years). Group 2: PSX patients with nuclear cataract (n=18, aged 50-90 years). Patients with other ophthalmic problems and systemic diseases were excluded. Vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) and nitrotyrosine levels were determined through serum samples by Enzyme -linked immunosorbent assay (ELISA) method. Nitrite-nitrate levels were measured with photometric endpoint determination. %26lt;br%26gt;RESULTS: There were no significant differences between the groups in terms of age, VEGF, IL-1 beta, nitrite-nitrate and nitrotyrosine. The significant results were the mean IL-6 levels that were higher in PSX group 2 (37.68 +/- 29.52 pg/mL) compared to that in control group 1 (15.32 +/- 10.08 pg/mL) (P%26lt;0.001). %26lt;br%26gt;CONCLUSION: Several interacting and extending biochemical pathways may lead to the promotion of VEGF and IL -6 expressions. IL -6 which is the only altered marker in our study may indirectly cause an increase of vascular permeability and neovascularization. We suggest inflammation as a factor that can be involved in etiopathogenesis of PSX.

• 出版日期2013-2-18