科研之友
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摘要
AT13387 is a novel HSP90 inhibitor, and it is currently used in clinical trials for the treatment of refractory gastrointestinal stromal tumors (GIST). In this article, two synthetic routes are described for synthesizing the title compound via [2+2+2] cycloaddition of dipropargylamine derivatives and propargyl alcohol as a key step. The alternate synthetic methods are economical and suitable for multigram-scale preparation of AT13387 and the related isoindoline derivatives.
- 出版日期2014
- 单位常州大学
