Association of serum leptin levels with central arterial stiffness in coronary artery disease patients

作者：Tsai Jen Pi; Wang Ji Hung; Chen Mei Ling; Yang Chiu Fen; Chen Yu Chih; Hsu Bang Gee^*

来源：BMC Cardiovascular Disorders, 2016, 16(1): 80.

DOI：10.1186/s12872-016-0268-5

• Arterial stiffness
• Carotid-femoral pulse wave velocity
• Coronary artery disease
• Leptin

Background: Serum adipokines have roles in the development of arterial stiffness. Our aim was to investigate the relationship of leptin and the surrogate marker carotid-femoral pulse wave velocity (cfPWV) in coronary artery disease (CAD) patients.
Methods: Fasting blood samples were obtained from 105 CAD patients. cfPWV was measured with the SphygmoCor system. A cfPWV > 10 m/s was defined as high arterial stiffness, and <= 10 m/s as low arterial stiffness.
Results: Thirty-seven patients (35.2 %) had high arterial stiffness, and had a higher percentage of diabetes (P = 0.001), hypertension (P = 0.010), older age (P = 0.001), and higher systolic blood pressure (SBP) (P < 0.001), diastolic blood pressure (DBP) (P = 0.021), pulse pressure (P = 0.014), and serum leptin level (P = 0.002) compared to patients with low arterial stiffness. Serum leptin levels correlated with the number of angiographically documented stenotic coronary artery vessels (P < 0.001). After adjusting for factors significantly associated with arterial stiffness, multivariate logistic regression analysis showed that leptin (odds ratio = 1.026, 95 % confidence interval: 1.002-1.051, P = 0.037) was a significant independent predictor of arterial stiffness.
Conclusions: Increasing serum concentration of leptin correlated positively with the total number of stenotic coronary arteries, and serum leptin level may predict the development of arterial stiffness in CAD patients.

• 出版日期2016-5-5