Anionic fluoroquinolones as antibacterials against biofilm-producing Pseudomonas aeruginosa

作者：Long Timothy E^*; Keding Lexie C; Lewis Demetria D; Anstead Michael I; Withers T Ryan; Yu Hongwei D

来源：Bioorganic & Medicinal Chemistry Letters, 2016, 26(4): 1305-1309.

DOI：10.1016/j.bmcl.2016.01.012

• Fluoroquinolone
• Pseudomonas
• Mucoid
• Biofilm
• Antibacterial

Pseudomonas aeruginosa is a common biofilm-forming bacterial pathogen implicated in diseases of the lungs. The extracellular polymeric substances (EPS) of respiratory Pseudomonas biofilms are largely comprised of anionic molecules such as rhamnolipids and alginate that promote a mucoid phenotype. In this Letter, we examine the ability of negatively-charged fluoroquinolones to transverse the EPS and inhibit the growth of mucoid P. aeruginosa. Anionic fluoroquinolones were further compared with standard antibiotics via a novel microdiffusion assay to evaluate drug penetration through pseudomonal alginate and respiratory mucus from a patient with cystic fibrosis.

• 出版日期2016-2-15