High-throughput approaches to understanding gene function and mapping network architecture in bacteria

作者：Brochado Ana Rita; Typas Athanasios^*

来源：Current Opinion in Microbiology, 2013, 16(2): 199-206.

DOI：10.1016/j.mib.2013.01.008

Advances in sequencing technology have provided an unprecedented view of bacterial diversity, along with a daunting number of novel genes. Within this new reality lies the challenge of developing large-scale approaches to assign function to the new genes and place them in pathways. Here, we highlight recent advances on this front, focusing on how high-throughput gene-gene, gene-drug and drug-drug interactions can yield functional and mechanistic inferences in bacteria.

• 出版日期2013-4