A randomized controlled trial of low-dose recombinant human interferons α-2b nasal spray to prevent acute viral respiratory infections in military recruits

作者：Gao, LuLu; Yu, Shouyi; Chen, Qing^*; Duan, Zhaojun; Zhou, Jie; Mao, Chen; Yu, Dexian; Zhu, Wenchang; Nie, Jun; Hou, Yunde

来源：Vaccine, 2010, 28(28): 4445-4451.

DOI：10.1016/j.vaccine.2010.03.062

• Recombinant human interferon alpha-2b
• Randomized controlled trial
• Viral respiratory infection
• Nasal spray

The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon alpha-2b (rIFN alpha-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized controlled trial. The results showed that application of the rIFN alpha-2b nasal spray had the benefits in prevention of infections caused by influenza A virus, influenza B virus parainfluenza viruses 1-3 and adenovirus species B. However, no benefit was seen in preventing respiratory syncytial virus. No severe adverse events were reported. Therefore, the rIFN alpha-2b nasal spray was effective and well tolerated for preventing common viral respiratory infections in the military recruits.

• 出版日期2010-6-17
• 单位中国疾病预防控制中心病毒病预防控制所; 南方医科大学