Delivery of tanshinone IIA and alpha-mangostin from gold/PEI/cyclodextrin nanoparticle platform designed for prostate cancer chemotherapy

作者：Qiu Shihong; Granet Robert; Mbakidi Jean Pierre; Bregier Frederique; Pouget Christelle; Micallef Ludovic; Sothea Ouk Tan; Leger David Y; Liagre Bertrand; Chaleix Vincent; Sol Vincent^*

来源：Bioorganic & Medicinal Chemistry Letters, 2016, 26(10): 2503-2506.

DOI：10.1016/j.bmcl.2016.03.097

• Gold nanoparticles
• PEI
• alpha-Mangostin
• Tanshinone IIA
• Prostate cancer cell lines

A new anti-cancer drug delivery system, based on gold nanoparticles, has been designed for hydrophobic active compounds. The system is a conjugate of gold/polyethyleneimine (AuNPs/PEI) nanoparticles and sulphated beta-cyclodextrin (CD). Anionic cyclodextrin was attached to the positively charged AuNPs/PEI nanoparticles by ionic bonds. Tanshinone IIA and alpha-mangostin were extracted, purified and encapsulated into the AuNPs/PEI/CD nanoparticles. In vitro preliminary cell viability assays against prostate cancer cell lines PC-3 and DU145 showed that encapsulation resulted in increased cytotoxicity.

• 出版日期2016-5-15