NK-cell fratricide Dynamic crosstalk between NK and cancer cells

作者:Nakamura Kyohei; Nakayama Masafumi; Kawano Mitsuko; Ishii Tomonori; Harigae Hideo; Ogasawara Kouetsu*
来源:OncoImmunology, 2013, 2(11): e26529.
DOI:10.4161/onci.26529

摘要

The intercellular transfer of plasma membrane patches, also known as trogocytosis, has a strong impact on the function and fate of immune cells. We have recently shown that natural killer (NK) cells undergo fratricide following the trogocytosis-mediated acquisition of tumor-derived NKG2D ligands. Malignant cells may therefore employ trogocytosis to escape NKG2D-mediated immune responses.

  • 出版日期2013-11