Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

作者：Bosetti C^*; Lucenteforte E; Bracci P M; Negri E; Neale R E; Risch H A; Olson S H; Gallinger S; Miller A B; Bueno de Mesquita H B; Talamini R; Polesel J; Ghadirian P; Baghurst P A; Zatonski W; Fontham E; Holly E A; Gao Y T; Yu H; Kurtz R C; Cotterchio M; Maisonneuve P; Zeegers M P; Duell E J; Boffetta P; La Vecchia C

来源：Annals of Oncology, 2013, 24(11): 2903-2910.

DOI：10.1093/annonc/mdt336

• anti-ulcer drugs
• case-control study
• gastrectomy
• pancreatic cancer
• peptic ulcer
• pooled analysis

Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. %26lt;br%26gt;We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. %26lt;br%26gt;The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. %26lt;br%26gt;This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.

• 出版日期2013-11
• 单位河北医科大学; 上海市肿瘤研究所