No evidence for association between polymorphisms in GRM3 and schizophrenia

作者：Norton Nadine; Williams Hywel J; Dwyer Sarah; Ivanov Dobril; Preece Anna C; Gerrish Amy; Williams Nigel M; Yerassimou Pamela; Zammit Stanley; O'Donovan Michael C^*; Owen Michael J

来源：BMC Psychiatry, 2005, 5: 23.

DOI：10.1186/1471-244X-5-23

Background: Three studies have previously reported data that were interpreted by the authors as supportive of association between schizophrenia and polymorphisms in the gene encoding the metabotropic glutamate receptor GRM3.
Methods: In a bid to examine this hypothesis, we examined seven SNPs spanning GRM3 in a UK case-control sample (schizophrenic cases n = 674, controls n = 716). These included all SNPs previously reported to be associated, alone or in haplotypes, with schizophrenia in European or European American samples.
Results: Our data showed no evidence for association with single markers, or 2, 3, 4 and 5 marker haplotypes, nor did any specific haplotypes show evidence for association according to previously observed patterns.
Conclusion: Examination of our own data and those of other groups leads us to conclude that at present, GRM3 should not be viewed as a gene for which there is replicated evidence for association with schizophrenia.

• 出版日期2005