A case report of placental mesenchymal dysplasia with an increased VEGF-D expression

作者：Kotani T^*; Sumigama S; Tsuda H; Mano Y; Yamamoto E; Iwase A; Shimoyama Y; Nagasaka T; Hayakawa H; Yamamoto T; Ino K; Kikkawa F

来源：Placenta, 2012, 33(10): 888-891.

DOI：10.1016/j.placenta.2012.07.015

• VEGF-D
• X-chromosome
• IUGR

The pathogenesis of placental mesenchymal dysplasia (PMD) remains unclear. This report presents a case of PMD with a female fetus complicated with intrauterine growth restriction (IUGR). The ultrasound findings were similar to molar pregnancies, but PMD was suspected based on the presence of low beta-hCG levels and a normal karyotype. After delivery, pathological examination of the placenta showed dilated villi and thick-walled vessels lacking trophoblast proliferation, which thus led to a diagnosis of PMD. The VEGF-D (Xp22.31) mRNA expression was found to have increased in the abnormal villi. Whether this is an incidental or X-linked gene specific event in, IUGR complicated, PMD pathogenesis warrants further investigation of VEGF-D expression in PMD.

• 出版日期2012-10