Melanocortin 1 receptor and skin pathophysiology: beyond colour, much more than meets the eye

作者：Carlos Garcia Borron Jose; Olivares Concepcion

来源：Experimental Dermatology, 2014, 23(6): 387-388.

DOI：10.1111/exd.12310

• collagen metabolism
• fibroblasts
• melanocortin 1 receptor
• skin fibrosis

The melanocortin 1 receptor (MC1R), a G protein-coupled receptor preferentially expressed in melanocytes, mediates the pigmentary effects of melanocyte-stimulating hormone (MSH). MC1R is also expressed in other cutaneous cell types, particularly keratinocytes and dermal fibroblasts, suggesting non-pigmentary actions of the MSH/MC1R system. Bohm and Stegemann now report a dramatic effect of mouse Mc1r functional status on susceptibility to skin fibrosis and collagen types I and III metabolism, in a study combining the powerful mouse model provided by the natural Mc1re/e knockout and an established model of skin fibrosis. The study underscores the antifibrotic role for the skin MSH/MC1R system.

• 出版日期2014-6