科研之友
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摘要
Background: For patients with melanoma metastases in the pelvic and groin regions, the median survival time (MST) was 8 mo with old treatments, whereas today is approximately 20 mo with new target therapy and novel immunotherapy. Unfortunately, approximately 30% of patients are nonresponsive to these new drugs. Materials and methods: Thirty-six patients, previously progressing after standard treatments, collectively received 146 melphalan (30 mg/m(2)) hypoxic pelvic perfusions with hemofiltration, in association with palliative excision in most cases. Results: The median follow-up time was 15 mo. Among 36 patients, three patients were alive without evidence of disease after 62, 95, and 118 mo, respectively. Thirty-three patients died of melanoma. The overall MST was 15 mo. The 5-y survival rate was 8%. The MST was 37 mo for stage IIIB; 19 mo for stage IIIC; and 6 mo for stage IV. The MST was 11 mo for patients with >= 1 mitosis per mm(2) and 20 mo for patients with <1 mitosis per mm(2); 17 mo for patients who received excision and 7 mo for patients who did not receive excision; and 19.5 mo for patients who received >2 treatments and 7.5 mo for patients who received <= 2 treatments. Conclusions: Pelvic/inguinal perfusion is a safe and feasible treatment for patients with
- 出版日期2017-7
