Birth of children with severe beta-thalassemia at a tertiary obstetric hospital: what are the reasons behind it?

作者：Yang, Yu; Li, Dong-Zhi^*

来源：Prenatal Diagnosis, 2013, 33(11): 1023-1026.

DOI：10.1002/pd.4189

• NONINVASIVE PRENATAL-DIAGNOSIS
• ALPHA-THALASSEMIA
• COMPLICATIONS
• DISEASES

ObjectiveTo find reasons for the births of severe -thalassemia at a tertiary obstetric hospital in mainland China.
MethodsAll cases with confirmed diagnosis of -thalassemia major were included from 1 January 2007 to 31 December 2011. The main clinical characteristics of the affected pregnancies were reviewed, including maternal reproductive history, prenatal care in the current pregnancy, the gestation of pregnancy at the time of booking, and availability of husbands for a screen test.
ResultsA total of nine cases of -thalassemia major were identified at birth during the study period. The reasons for no prenatal diagnosis included unavailability of the father for a test in four cases, unacceptability of the invasive procedure in two cases, absence of prenatal care in two cases, and nonpaternity in one case.
ConclusionThe effectiveness in control of the disease is not only associated with the model itself but also the factors playing against the model. The identification of the main reasons for the birth of severe thalassemia might help to find room for improvement in clinical practice.

• 出版日期2013-11
• 单位广州市妇女儿童医疗中心; 广州医科大学