Development and perspective of current Brazilian studies on the epidemiology of childhood leukemia

作者：Pombo de Oliveira Maria S; Koifman Sergio; Vasconcelos Gisele M; Emerenciano Mariana; Novaes Cristiane de Oliveira

来源：Blood Cells, Molecules, and Diseases, 2009, 42(2): 121-125.

DOI：10.1016/j.bcmd.2008.10.012

• Childhood leukemia
• Genetic polymorphisms
• Environmental risk factors
• Transplacental exposure
• Risk

In this concise report, we describe the history and evolution of childhood acute leukemia studies in Brazil, and the application if key biomarkers for clinical trials and epidemiological studies over the past 8 years. Highlights of each ongoing study are summarized. A Brazilian network integrating hospitals and scientific institutions from all country regions has been established. This organization is made possible through informatics and computer networking, and the standardization of pathological reviews including immunophenotyping and molecular characterization of childhood leukemias. The unique characteristics of the Brazilian population combined with a large clinical and epidemiologic framework for patient ascertainment has enabled large-scale epidemiological studies on childhood leukemia in Brazil.

• 出版日期2009-4