Atomic evidence that modification of H-bonds established with amino acids critical for host-cell binding induces sterile immunity against malaria

作者：Patarroyo Manuel E^*; Cifuentes Gladys; Pirajan Camilo; Moreno Vranich Armando; Vanegas Magnolia

来源：Biochemical and Biophysical Research Communications, 2010, 394(3): 529-535.

DOI：10.1016/j.bbrc.2010.03.004

• Malaria
• Plasmodium falciparum
• Sterile immunity
• H-bonds

Based on the 3D X-ray crystallographic structures of relevant proteins of the malaria parasite involved in invasion to host cells and 3D NMR structures of High Activity Binding Peptides (HABPs) and their respective analogues, it was found that HABPs are rendered into highly immunogenic and sterile immunity inducers in the Aotus experimental model by modifying those amino acids that establish H-bonds with other HABPs or binding to host's cells This finding adds striking and no

• 出版日期2010-4-9