A copper coordination compound produced by a marine fungus Fusarium sp ZZF51 with biosorption of Cu(II) ions

作者：Tan Ni^*; Pan Jia-Hui; Peng Guang-Tian; Mou Cheng-Bo; Tao Yi-Wen; She Zhi-Gang; Yang Ze-Liang; Zhou Shi-Ning; Lin Yong-Cheng

来源：Chinese Journal of Chemistry, 2008, 26(3): 516-521.

DOI：10.1002/cjoc.200890097

• copper coordination compound
• bis(5-butyl-2-pyridinecarboxylato-N1,O2)-copper
• mutagenicity
• complex constant
• endurance
• biosorption

A copper coordination compound ZZF51(A) named bis(5-butyl-2-pyridinecarboxylato-N1,O2)-copper, the first time found in the nature, was isolated from a marine endophytic fungus Fusarium sp, ZZF51 from the South China Sea coast. Its structure was elucidated using spectroscopic methods and single crystal X-ray diffraction analysis. The antimicrobial cytotoxicity experiments exhibited that ZZF51(A) had mutagenicity activities against four aerobic reference strains Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Salmonella enteritidis with respective MIC values of 12.5, 25, 12.5, and 50 mu g/mL. The anti-cancer tests showed that the compound had strong inhibitory activities against three human cancer lines KB, KBv200, and HepG2 with IC(50) values of 3.54, 3.68 and 25.12 mu g/mL respectively. In the course of investigating the source of ZZF51(A) in biomass, it was found that the output of ZZF51(A) was largely influenced by the amount of CuCl(2) in the liquid medium, and the fungus (No. ZZF51) had two notable characteristics: endurance of high concentration Cu(II) ions and biosorption of Cu(II) ions.

• 出版日期2008-3
• 单位南华大学; 中山大学; 有害生物控制与资源利用国家重点实验室