Autoimmune spread to myelin is associated with experimental autoimmune encephalomyelitis induced by a neuronal protein, beta-Synuclein

作者：Kela Madar Neta; de Ro**o Nicole Kerlero; Ronen Ayal; Mor Felix; Ben Nun Avraham^*

来源：Journal of Neuroimmunology, 2009, 208(1-2): 19-29.

DOI：10.1016/j.jneuroim.2008.12.009

• Autoimmunity
• Autoantibodies
• T cells
• Antigens/peptides/epitopes
• Rodent

Accumulating evidence suggests that autoimmunity against neuronal proteins is important for MS pathogenesis. We have characterized T- and B-cell responses associated with experimental autoimmune encephalomyelitis (EAE) induced in Lewis rats with recombinant beta-Synuclein (beta Sync), a neuronal component. The encephalitogenic beta Sync-specific T cells recognize a single immunodominant region with an epitope delineated at amino acids 97-105; B-cell specificity is more widespread, albeit directed mostly to the C-terminus of beta Sync. Most interestingly, beta Sync-induced autoimmune T- and B-cell responses spread not only to other neuronal antigens but also to myelin encephalitogens, raising the possibility that anti-neuronal immune attacks could also result in demyelination.

• 出版日期2009-3-31