A Generalized Correlation Coefficient for the General Two-Treatment Crossover Design

作者：Chen Vivian Yi Ju^*; Chinchilli Vernon M

来源：Communications in Statistics - Theory and Methods, 2010, 39(11): 2063-2080.

DOI：10.1080/03610920902969026

• Bootstrap
• Correlation coefficient
• Crossover design
• U-Statistics

This article extends the correlation methodology developed by Chinchilli et al. (2005) for the 2x2 crossover design to more complex crossover designs for clinical trials. We describe how the methodology can be adapted to a general type of two-treatment crossover design which includes either at least two sequences or at least two treatment periods or both. We then derive the asymptotic theory for the corresponding correlation statistics, investigate the statistical accuracy of the estimators via bootstrap analyses, and demonstrate their use with two real data examples.

• 出版日期2010