Association of HIV transmission categories with sociodemographic, viroimmunological and clinical parameters of HIV-infected patients

作者：Collazos J^*; Asensi V; Carton J A

来源：Epidemiology and Infection, 2010, 138(7): 1016-1024.

DOI：10.1017/S0950268809991282

• CD4 counts
• clinical outcomes
• epidemiological factors
• HIV transmission categories
• viral load

To analyse sociodemographic, viroimmunological and clinical parameters in different HIV-transmission categories at baseline and during treatment, 3039 patients were followed up for 12 months after the initiation of a nelfinavir-based regimen. Multiple baseline parameters were significantly different in the diverse categories, including CD4 counts (P<0.0001) and viral load (P = 0.02). There were differences in the groups regarding the CD4 response (P = 0.01), but not the virological response (P = 0.4), to therapy over time. Multivariate analyses revealed that transmission categories were significantly related to baseline CD4 counts (P = 0.01), viral load at 12 months (P = 0.0006), poorer adherence to therapy of injecting drug users (IDUs) vs. each of the other groups (P < 0.001) and failure to complete the 12-month evaluation of IDU vs. heterosexual (P = 0.003) and men who have sex with men (MSM) groups (P = 0.02). We conclude that transmission categories had a significant influence on several baseline parameters and viroimmunological outcomes following highly active antiretroviral therapy (HAART), as well as on adherence to therapy and to medical appointments.

• 出版日期2010-7