Individual radiosensitivity and health risks from exposure to low levels of medical ionizing radiation

作者：Bourguignon M^*; Foray N; Colin C; Pauwels E

来源：Medecine Nucleaire-Imagerie Fonctionnelle et Metabolique, 2012, 36(7): 424-428.

DOI：10.1016/j.mednuc.2012.05.006

• Radiosensitivity
• Low-doses
• Cancer susceptibility
• Mammography
• DNA
• Double-strand break

Individual radiosensitivity to high doses of ionizing radiations has been known for a long time by radiation oncologists. It is responsible for the side effects and complications of radiation therapy in the absence of errors in dose delivery. Immunofluorescence techniques have lowered by a factor 100 the threshold of detection of DNA double-strand breaks, to the level of 1 mGy. The effects of a simple radiography, e.g. a mammography, can be measured. Thus the phenomenon of individual radiosensitivity at low-doses has been assessed in mammary epithelium cell cultures exposed in the conditions of mammography. The mechanisms of individual radiosensitivity are linked to abnormalities of DNA damage signalling and repair. This suggests a link between cancer proneness and radiosensitivity. Individual radiosensitivity has a prevalence of 5 to 15% in the population. Thus, it is a key phenomenon to take into account in public health and in future recommendations of the radioprotection system.

• 出版日期2012-7