科研之友
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摘要
A new graphical representation for protein sequences is introduced in this paper. We firstly construct a 3D space discrete point set for amino acids of protein sequences based on three physicochemical properties of amino acids. Then, we use a cubic Bezier spline curve to interpolate these discrete points to represent protein sequences. Different from many traditional and current graphical representations of protein sequences, our curve is smooth, continuous and parametric, we can easily apply the geometric property of the curve for the similarity analysis. We finally use the curvature frequencies of protein curves to analyze the similarity of protein sequences by comparing the distance of vectors. As an example, we take ND5 proteins from nine different species to illustrate our method. The experimental results show that our proposed method is effective for the similarity analysis of proteins.
- 出版日期2014
- 单位浙江理工大学
