Bi-directional regulation of emodin and quercetin on smooth muscle myosin of gizzard

作者：Zhang HL; Tang ZY; Yang JX; Zhang Y; Li Y; Lin Y^*

来源：FEBS Letters, 2006, 580(2): 469-473.

DOI：10.1016/j.febslet.2005.12.041

• emodin
• quercetin
• myosin Mg2+-ATPase activity
• myosin phosphorylation
• bidirectional regulation

This study is to reveal the characteristics of bidirectional regulation of emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and quercetin on gizzard smooth muscle myosin. Our results indicate that: (a) emodin demonstrates stimulatory effects, and quercetin produces inhibitory effects on myosin phosphorylation and Mg2+-ATPase activities of Ca2+/calmodulin-dependent phosphorylated myosin in a dose-dependent manner; (b) a combination of emodin and quercetin enhances phosphorylation and Mg2+-ATPase activities for partially phosphorylated myosin and inhibits those activities for fully phosphorylated myosin; (c) 1-(5-Chloronaphthalene-1-sulfonyl)-1H2-hexahydro-1,4diazepine inhibits myosin phosphorylation in the presence of emodin and/or quercetin. A combination of emodin and quercetin indicates its potential for modulating gastric-intestinal smooth muscle.

• 出版日期2006-1-23
• 单位大连医科大学