Association of thioredoxin reductase 2 (TXNRD2) gene polymorphisms with myocardial infarction in Slovene patients with type 2 diabetes mellitus

作者：Kariz Stojan; Mankoc Sara; Petrovic Daniel^*

来源：Diabetes Research and Clinical Practice, 2015, 108(2): 323-328.

DOI：10.1016/j.diabres.2015.01.038

• Oxidative stress
• Thioredoxin reductase 2
• Genetic polymorphisms
• Type 2 diabetes mellitus
• Myocardial infarction

Objectives: The aim of our study was to investigate the relationship between genetic polymorphisms in the mitochondrial thioredoxin reductase 2 (TrxR2) and myocardial infarction (MI) in subjects with type 2 diabetes mellitus (T2DM) of Slovenian origin.
Methods: The study population consisted of 972 Caucasian subjects with T2DM of more than 10 years' duration: 161 patients with MI and 811 patients with no history of coronary artery disease. Polymorphisms in thioredoxin reductase 2 (TXNRD2) gene, rs1548357, rs4485648, and rs5748469, were studied.
Results: Individuals carrying CC + CT genotypes of rs1548357 TXNRD2 polymorphism had lower prevalence of MI compared with TT genotype group (41.6% vs 52.8%, OR = 0.589, 95% CI = 0.368-0.942, P = 0.027).
Conclusions: The TXNRD2 rs 1548357 polymorphism might be a genetic risk factor for MI in subjects with T2DM of Slovenian origin.

• 出版日期2015-5