AgNO2-mediated direct nitration of the quinoxaline tertiary benzylic C-H bond and direct conversion of 2-methyl quinoxalines into related nitriles

Wu, Degui; Zhang, Jian; Cui, Jianhai; Zhang, Wei; Liu, Yunkui<sup>*</sup>

doi:10.1039/c4cc01327a

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AgNO2-mediated direct nitration of the quinoxaline tertiary benzylic C-H bond and direct conversion of 2-methyl quinoxalines into related nitriles

作者：Wu, Degui; Zhang, Jian; Cui, Jianhai; Zhang, Wei; Liu, Yunkui^*

来源：Chemical communications, 2014, 50(74): 10857-10860.

DOI：10.1039/c4cc01327a

摘要

A unique method for AgNO2-mediated direct nitration of the quinoxaline tertiary C-H bond and direct conversion of 2-methyl quinoxalines into 2-quinoxaline nitriles under oxidative conditions has been developed. This protocol provides an efficient way to access quinoxaline containing nitroalkanes and nitriles depending on different substrate selection.