Feasibility of capillary liquid chromatography-microchip-atmospheric pressure photoionization-mass spectrometry for pesticide analysis in tomato

作者：Kruve Anneli; Haapala Markus; Saarela Ville; Franssila Sami; Kostiainen Risto; Kotiaho Tapio; Ketola Raimo A^*

来源：Analytica Chimica Acta, 2011, 696(1-2): 77-83.

DOI：10.1016/j.aca.2011.04.006

• Pesticide analysis
• Carbamate pesticide
• Tomato
• Liquid chromatography
• Mass spectrometry
• Heated nebulizer microchip
• Atmospheric pressure photoionization

A new and sensitive analytical method, using capillary liquid chromatography (capLC) with a microfabricated heated nebulizer chip for atmospheric pressure photoionization and tandem mass spectrometry (mu APPI-MS/MS), was developed for the analysis of selected carbamate pesticides in a tomato matrix. The performance of the instrumental method was evaluated, using seven pesticides, namely oxamyl, methomyl, aldicarb, carbofuran, pirimicarb, thiocarb, and ditalimfos. The limits of detection achieved with the capLC-mu APPI-MS/MS method in the positive ion mode were low, ranging from 0.25 ng mL(-1) for pirimicarb to 5 ng mL(-1) for oxamyl and methomyl. corresponding to 5 and 0.25 mu g kg(-1) for tomato samples, respectively, which are clearly below the maximum residue limits for them in fruits and vegetables. The repeatability of the instrumental method ranged from 2.9 to 13.9% (RSD) at slow (0.05 mu g m L(-1)) concentration level. An adequate linearity (r(2) = 0.984-0.999) at a concentration range from 0.005 to 5.0 mu g mL(-1) was observed for all pesticides. The results obtained show that the capLC-mu APPI-MS/MS method developed could be used for the analysis of selected pesticides from tomato.

• 出版日期2011-6-24