New unsaturated polyesters as injectable drug carriers

作者：Guo, Wen xun^*; Shi, Zong li; Liang, Kui; Liu, Yan li; Chen, Xian hong; Li, Wei

来源：Polymer Degradation and Stability, 2007, 92(3): 407-413.

DOI：10.1016/j.polymdegradstab.2006.11.018

• unsaturated polyester
• copolymer
• drug release
• adriamycin hydrochloride
• antitumor efficacy

New unsaturated polyesters of poly(fumaric acid-glycol-sebacic acid) copolymers and poly(maleic anhydride-glycol-sebacic acid) copolymers were prepared by melt polycondensation of the corresponding mixed monomers: sebacic anhydride, fumaric acid or maleic anhydride and glycol. Methyl-methacrylate (MMA) was used as crosslinker and dimer acid was used as thinner.
In vitro studies showed that those copolymers are degradable in phosphate buffer at 37 degrees C and poly(fumaric acid-glycol-sebacic acid) has proper drug release rate as drug carriers. The biocompatibility of poly(fumaric acid-glycol-sebacic acid) copolymers under mice skin was also evaluated; macroscopic observation and microscopic analysis demonstrated that the copolymer is biocompatible and well tolerated in vivo. The injected poly(fumaric acid-glycol-sebacic acid) [molar ratio M-fumar acid:M-glycol:M-sebacic acid = 1.75:2.20:0.25] containing 5% adriamycin hydrochloride (ADM) in the mice bearing Sarcoma-180 tumor exhibited a good antitumor efficacy. The volume doubling time (VDT) (18 +/- 2.5 days) of the tumor growth by this treatment was longer than that (7 +/- 0.9 days) by the subcutaneous injection of ADM.

• 出版日期2007-3
• 单位湖南大学