An Insertion/Deletion Polymorphism at miRNA-122 Binding Site in the IL1A Is Associated with a Reduced Risk of Cervical Squamous Cell Carcinoma

作者：Huang, Juan; Ni, Shanshan; Li, Danqing; He, Yuedong^*

来源：Genetic Testing and Molecular Biomarkers, 2015, 19(6): 331-334.

DOI：10.1089/gtmb.2015.0015

• HUMAN-PAPILLOMAVIRUS
• FUNCTIONAL POLYMORPHISM
• ENHANCES ANGIOGENESIS
• CANCER
• INTERLEUKIN-1-ALPHA
• GENE
• MICRORNAS
• RELEASE
• TRENDS

Objective: Previous studies have shown that miRNA plays a key role in cervical carcinogenesis. Interleukin (IL)-1 can promote tumor growth, invasion, migration, and angiogenesis. An insertion/deletion polymorphism (rs3783553) in the IL1A 3 untranslated region may disrupt a binding site for miR-122 and miR-378 and thus change the transcription of IL-1. The purpose of this study was to evaluate the association between the rs3783553 polymorphism and the risk of cervical squamous cell carcinoma (CSCC). Methods: Polymerase chain reaction was used to genotype the IL1A rs3783553 polymorphism in 235 patients with CSCC and 326 controls. Results: We found that the ins/ins genotype had a decreased risk to develop CSCC (odds ratio [OR]=0.48, 95% confidence interval [CI], 0.25-0.95). However, no significant association was observed between the IL1A rs3783553 genotype and clinical features. Conclusion: These findings indicate that the IL1A rs3783553 polymorphism may be associated with the etiology of CSCC.

• 出版日期2015-6-1
• 单位四川大学