Delta FosB Regulates Gene Expression and Cognitive Dysfunction in a Mouse Model of Alzheimer's Disease

作者：Corbett Brian F; You Jason C; Zhang Xiaohong; Pyfer Mark S; Tosi Umberto; Iascone Daniel M; Petrof Iraklis; Hazra Anupam; Fu Chia Hsuan; Stephens Gabriel S; Ashok Annie A; Aschmies Suzan; Zhao Lijuan; Nestler Eric J; Chin Jeannie^*

来源：Cell Reports, 2017, 20(2): 344-355.

DOI：10.1016/j.celrep.2017.06.040

Alzheimer's disease (AD) is characterized by cognitive decline and 5-to10- fold increased seizure incidence. How seizures contribute to cognitive decline in AD or other disorders is unclear. We show that spontaneous seizures increase expression of Delta FosB, a highly stable Fos-family transcription factor, in the hippocampus of an AD mouse model. DFosB suppressed expression of the immediate early gene c-Fos, which is critical for plasticity and cognition, by binding its promoter and triggering histone deacetylation. Acute histone deacetylase (HDAC) inhibition or inhibition of DFosB activity restored c-Fos induction and improved cognition in AD mice. Administration of seizure-inducing agents to nontransgenic mice also resulted in Delta FosB-mediated suppression of c-Fos, suggesting that this mechanism is not confined to AD mice. These results explain observations that c-Fos expression increases after acute neuronal activity but decreases with chronic activity. Moreover, these results indicate a general mechanism by which seizures contribute to persistent cognitive deficits, even during seizure-free periods.

• 出版日期2017-7-11