Antihyperlipidemic glycosides from the root bark of Lycium chinense

作者:Chen, Hui*; Li, Yu-Jie; Sun, Yan-Jun; Li, Xiao-Kun*; Jian-Hong, Gong; Wu, Ya; Su, Fang-Yi; Du, Kun; Zhang, Yan-Li; Feng, Wei-Sheng
来源:Natural Product Research, 2019, 33(18): 2655-2661.
DOI:10.1080/14786419.2018.1466125

摘要

Three new glycosides (1-3), together with six known ones (4-9), were isolated from the root bark of Lycium chinense. Their structures were elucidated on the basis of MS and NMR spectroscopic data. Five compounds (3, 5, 6, 8, and 9) exhibited potent antihyperlipidemic activities in HepG2 cells as assessed by Oil Red O staining and significant inhibition of intracellular triglyceride (TG) levels, whereas two compounds (5 and 9) significantly reduced total cholesterol (TC) levels. [GRAPHICS] .