Anti-Apoptosis Effects on Hearts of SHSST Cyclodextrin Complex in a Carbon Tetrachloride-Induced Cirrhotic Cardiomyopathy Rat Model

作者：Yang Cheng Hsun; Ting Wei Jen; Pai Pei Ying; Chang Sheng Huang; Ho Tsung Jung; Lin Jing Ying; Tsai Fuu Jen; Padama Viswanadha Vijaya; Tsai Yuhsin; Huang Chih Yang^*

来源：Chinese Journal of Physiology, 2015, 58(1): 38-45.

DOI：10.4077/CJP.2015.BAD286

• baicalein
• beta-cyclodextrin modified SHSST
• cirrhotic cardiomyopathy
• silymarin

Cirrhotic cardiomyopathy (CCM) is a common cardiac dysfunction in patients waiting for orthotopic liver transplantation (OLT). Carbon tetrachloride (CCI4) intraperitoneal (IF) injection has been reported as successful in a cirrhosis-induced CCM model. In this work, we used the same assay for CCM induction using CCI4 (0.2 mg/kg) IP injection twice per day for 14 days during the cardiac protection drugs treatment process. The cardiac protection drugs were silymarin (100 mg/kg/day), baicalein (30 mg/kg/day), San Huang Shel Shin Tang (SHSST, 30 mg/kg/day) and beta-cyclodextrin modified SHSST (SHSSTc, 30 mg/kg/day and 300 mg/kg/day). After 4 weeks of treatment, the SHSSTc cardiac protection effects were determined through activation of the IGF1R cell survival pathway and inhibition of Fas-FADD death domain induced-apoptosis. SHSSTc cardiac protection was enhanced through beta-cyclodextrin modification, which increased bio-availability, and displayed stronger protective effects than silymarin and baicalein, both of which are well-known liver protection drugs. Thus, SHSSTc might provide the best therapeutic benefit in CCM treatment.

• 出版日期2015-2-28
• 单位中国医科大学