A concise total synthesis of hymenialdisine

作者：Saleem Rahman Shah Zaib; Tepe Jetze J^*

来源：Tetrahedron Letters, 2015, 56(23): 3011-3013.

DOI：10.1016/j.tetlet.2014.10.022

• Natural product
• Hymenialdisine
• Total synthesis
• Heterocycles
• Antitumor agents

The synthesis of hymenialdisine has offered challenges that included the formation of the regio-isomers upon monobromination, atom-scrambling in the cyclization step, and low to moderate yields in the last steps. We herein present a short and concise (6 overall steps), high yielding route (44% overall yields) for this biologically interesting natural product that addresses these issues and avoids the use of any protecting groups.

• 出版日期2015-6-3