Burn injury: Challenges and advances in burn wound healing, infection, pain and scarring

作者：Wang Yiwei; Beekman Joanneke; Hew Jonathan; Jackson Stuart; Issler Fisher Andrea C; Parungao Roxanne; Lajevardi Sepher S; Li Zhe; Maitz Peter K M^*

来源：Advanced Drug Delivery Reviews, 2018, 123: 3-17.

DOI：10.1016/j.addr.2017.09.018

• Severe burn injuries
• Burn wound infections
• Burn pain management
• Scarring
• Skin tissue engineering
• Stem cells
• Negative pressure wound therapy
• Laser therapy for scarring

Severe burn injuries are the most traumatic and physically debilitating injuries affecting nearly every organ system and leading to significant morbidity and mortality. Early bum wound excision and skin grafting are common clinical practices that have significantly improved the outcomes for severe burn injured patients by reducing mortality rate and days of hospital stay. However, slow wound healing, infection, pain, and hypertrophic scarring continue to remain a major challenge in burn research and management. In the present article, we review and discuss issues in the current treatment of burn injuries; the advances and novel strategies developed in the past decade that have improved burn management; and also, pioneer ideas and studies in burn research which aims to enhance bum wound care with a focus on burn wound infection, pain management, treatments for scarring and skin tissue engineering.

• 出版日期2018-1-1