A Radical Signal Activates the Epigenetic Regulation of Longevity

作者:Mirisola Mario G; Longo Valter D*
来源:Cell Metabolism, 2013, 17(6): 812-813.
DOI:10.1016/j.cmet.2013.05.015

摘要

Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.

  • 出版日期2013-6-4