A Randomized Trial Evaluating the Effect of 2 Regimens of Maternal Vitamin A Supplementation on Breast Milk Retinol Levels

作者：Bezerra Danielle Soares; de Araujo Katherine Feitosa; Martins Azevedo Gabrielle Mahara; Dimenstein Roberto^*

来源：Journal of Human Lactation, 2010, 26(2): 148-156.

DOI：10.1177/0890334409356445

• supplementation
• postpartum
• vitamin A
• breast milk
• HPLC

The aim of this study was to assess the effect of 2 different megadoses of retinyl palmitate on the level of retinol in the breast milk of healthy women. In total, 199 women were randomly allocated to 3 groups and supplemented in the postpartum period with a single retinyl palmitate dose of 200 000 IU (S1), a double dose of 200 000 IU 24 hours apart (S2), or no supplementation (C). Retinol content of colostrum and mature milk at 4 weeks was determined by high-performance liquid chromatography (HPLC). For colostrum, no significant difference was found between the groups (P = .965). The retinol content in mature milk differed between group C and groups S1 and S2 (P < .05). The double dose of vitamin A did not significantly increase the retinol content of milk at 4 weeks postpartum in comparison to a single dose; however, future research is needed to determine the optimal timing of the second dose of vitamin A. J Hum Lact. 26(2):148-156

• 出版日期2010-5