Association of polymorphism variation in interleukin-8 with the risk of developing acute pancreatitis

作者：Yang, Wanguang^*; Wang, Wanpeng; Zhu, Changju; Liu, Yongfu; Guo, Guancheng; Xue, Jianfeng

来源：International Journal of Clinical and Experimental Pathology, 2016, 9(11): 11958-11964.

• IL-8
• polymorphism
• acute pancreatitis

The etiology of acute pancreatitis has been widely studied, but the mechanisms of this disease is not well clear. In our study, we performed a study in a Chinese population, and firstly evaluate the role of IL-8-251A/T, -353A/T and +781C/T polymorphisms in the risk of acute pancreatitis. This study comprises of 315 acute pancreatitis patients and 376 controls from the First Affiliated Hospital of Zhengzhou University between December 2012 and April 2015. The genotyping of IL-8-251A/T, -353A/T and +781C/T was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The unconditional logistic regression analysis revealed a relationship between the TT genotype of IL-8-251A/T and an increased risk of acute pancreatitis (adjusted OR=2.88, 95% CI=1.84-4.53), compared to the AA genotype. In the dominant and recessive genetic models, the IL-8-251A/T polymorphism was significantly correlated with an elevated risk of acute pancreatitis, and the adjusted Ors (95% CI) for dominant and recessive models were 1.57 (1.11-2.24) and 2.62 (1.80-3.82), respectively. However, no significant differences were observed between IL-8-353A/T and +781C/T polymorphisms and risk of acute pancreatitis. In conclusion, the present study has shown that the IL-8-251A/T polymorphism was significantly associated with an increased risk of acute pancreatitis in a Chinese population.

• 出版日期2016
• 单位郑州大学