Nitro-Triarylmethyl Radical as Dual Oxygen and Superoxide Probe

作者：Driesschaert Benoit^*; Bobko Andrey A; Khramtsov Valery V^*; Zweier Jay L^*

来源：Cell Biochemistry and Biophysics, 2017, 75(2): 241-246.

DOI：10.1007/s12013-016-0732-y

• EPR
• Superoxide
• Trityl
• Oxygen
• ROS

Superoxide radical is involved in numerous physiological and pathophysiological processes. Tetrathiatriarylmethyl (TAM) radicals are known to react with superoxide allowing measurement of superoxide production in biological media. We report the synthesis of a Nitro conjugated TAM radical showing a rate constant of 7 x 10(5) M-1 s(-1) which is two order of magnitude higher than other TAMs, allowing high sensitivity measurement of superoxide.

• 出版日期2017-6