Microwave-Assisted One-Pot Synthesis of Pyrazolo[3,4-b]indoles and New Isoxazolo[5,4-b]indoles via Copper-Catalyzed Intramolecular C-N/C-O Bond Formation

作者：Kumar Arepalli Sateesh; Rao P V Amulya; Nagarajan Rajagopal^*

来源：Synthesis, 2011, (23): 3878-3886.

DOI：10.1055/s-0031-1289572

• copper catalysis
• 3-acyl-2-chloroindoles
• pyrazolo[3,4-b]indoles
• isoxazolo[5,4-b]indoles
• intramolecular heteroarylation

A facile one-pot, two-step synthesis of highly substituted pyrazolo[3,4-b] indoles and isoxazolo[5,4-b] indoles was developed via microwave-assisted, copper-catalyzed intramolecular heterocyclization (involving C-N/C-O bond formation) from 3-acetyl-2-chloroindoles in good to excellent yields.

• 出版日期2011-12