Asymmetric organocatalytic oxy-Michael addition of alcohols to alpha,beta-unsaturated aldehydes

作者：Kano Taichi; Tanaka Youhei; Maruoka Keiji^*

来源：Tetrahedron, 2007, 63(35): 8658-8664.

DOI：10.1016/j.tet.2007.03.179

• oxy-michael addition
• alpha,beta-unsaturated aldehyde
• organocatalyst
• iminium catalysis

A 1,4-addition of alcohols to alpha,beta-unsaturated aldehydes was found to be efficiently promoted by biphenyldiamine-based catalyst 3 without formation of the acetals. An asymmetric variant of this reaction has also been performed by designing a novel axially chiral organo-catalyst (R)-10c.

• 出版日期2007-8-27