Applications for nitric oxide in halting proliferation of tumor cells

作者：Reynolds Melissa M; Witzeling Scott D; Damodaran Vinod B; Medeiros Tysha N; Knodle Ryan D; Edwards Melissa A; Lookian Pashayar P; Brown Mark A^*

来源：Biochemical and Biophysical Research Communications, 2013, 431(4): 647-651.

DOI：10.1016/j.bbrc.2013.01.041

• Nitric oxide
• Cancer therapy
• Adjuvant therapy
• Pro-drugs
• Cell signaling

Tumor resistance to cytotoxic therapeutics coupled with dose-limiting toxicity is a serious hurdle in the field of medical oncology. In the face of this obstacle, nitric oxide has emerged as a powerful adjuvant for the hypersensitization of tumors to more traditional chemo- and radio-therapeutics. Furthermore, emerging evidence indicates that nitric oxide donors have the potential to function independently in the clinical management of cancer. Herein, we discuss the role of nitric oxide in cancer and the potential for nitric oxide donors to support conventional therapeutics.

• 出版日期2013-2-22