Glycogen Phosphorylase: A Novel Biomarker in Doxorubicin-Induced Cardiac Injury

作者:Zhu Yueming; Gius David*
来源:Clinical Cancer Research, 2018, 24(7): 1516-1517.
DOI:10.1158/1078-0432.CCR-17-3276

摘要

Extracellular vesicles containing glycogen phosphorylase, brain/ heart (PYGB) have been demonstrated as a sensitive biomarker for normal cardiac injuries for patients after chemotherapy. Oxidative stress was suggested to be the mechanism behind the chemotherapy-induced tissue damage and augmented with mitochondrial antioxidant could be an effective means of early intervention.