A novel compound from Flos carthami and its bioactivity

作者：Zhang Ge^*; Guo Mei Li; Li Run Ping; Li Ying; Zhang Han Ming; Su Zhong Wu

来源：Chemistry of Natural Compounds, 2009, 45(3): 398-401.

DOI：10.1007/s10600-009-9333-y

• Flos carthami
• 4-{1 '-hydroxy-1 '-mercapto-1 '-[1 ''-2 ''(N -> O)-isoquinolyl]}yl-1-benzoic acid
• cerebral ischemic damage

A novel compound, 4-{1'-hydroxy-1'-mercapto-1'-[1''-2''(N -> O)-isoquinolyl]}yl-1-benzoic acid (1), together with six known compounds, 6-hydroxykaempferol-3-O-beta-D-glucopyranoside (2), rutin (3), quercetin-3-O-beta-D-glucopyranoside (4), kaempferol-3-O-beta-D-glucopyranoside (5), cartormin (6), hydroxysafflor yellow A (7), were isolated by chromatography from the n-BuOH fraction of 50% ethanol extraction of Flos carthami. Their structures were elucidated on the basis of spectral analysis and comparison with published data. Among them, compound 1 was shown to possess a weak protective effect against cerebral ischemic damage in rats.

• 出版日期2009-5
• 单位中国人民解放军第二军医大学