Disease Ontology-based Methods for Disease Similarity Measurement

作者：Li Jie^*; Chu Yan Shuo; Cheng Liang; Wang Ya Dong; Kong Lei Lei

来源：Progress in Biochemistry and Biophysics, 2015, 42(2): 115-122.

DOI：10.16476/j.pibb.2014.0140

• disease ontology
• disease similarity

Disease similarity studies for understanding the pathogenesis of complex diseases, diagnosis, prognosis and drug development are important. Recently, researchers constructed Disease Ontology disease (DO) by integrating a variety of disease terms, which builds up the foundation of disease similarity measurement based on DO. We summary disease similarity calculation methods based on DO-related information in this paper and discuss the issues and challenges in disease similarity measurement, offer helpful reference for further research.

• 出版日期2015-2
• 单位哈尔滨工业大学; 黑龙江工程学院